Sarcoidosis: Difference between revisions
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==Background== | ==Background== | ||
*Abnormal collection of inflammatory cells ( | *Abnormal collection of inflammatory cells (granulomas) throughout the body. | ||
**Most common location for granulomas to occur are the lung, skin, heart, and brain. | **Most common location for granulomas to occur are the lung, skin, heart, and brain. | ||
**Exact cause unknown - thought to be related to an immune reaction to a prior insult such as infection or chemical exposure earlier in life. | **Exact cause unknown - thought to be related to an immune reaction to a prior insult such as infection or chemical exposure earlier in life. | ||
Revision as of 22:52, 22 January 2018
Background
- Abnormal collection of inflammatory cells (granulomas) throughout the body.
- Most common location for granulomas to occur are the lung, skin, heart, and brain.
- Exact cause unknown - thought to be related to an immune reaction to a prior insult such as infection or chemical exposure earlier in life.
- Do not confuse with infectious granulomatous processes such as tuberculosis.
Clinical Features
Depend on location of granulomata. May be entirely asymptomatic.
- Respiratory
- Due to pulmonary granulomata
- Shortness of breath
- Cough
- Pulmonary hypertension
- Pulmonary abscesses/empyema
- Pneumothorax
- Erythema nodosum and other skin lesions
- Fatigue
- Weight loss
- Arthralgias
- Cardiopulmonary
- Restrictive cardiomyopathy
- Arrythmias due to conduction disturbance
- Endocrine
- Ocular
- Dacryoadenitis (lacrimal duct inflammation)
- Optic neuritis
- Iritis
Differential Diagnosis
- Malignancy
- Tuberculosis
- Coccidioidomycosis
- Histiocytosis X
- Wegener's granulomatosis
- Churg-Strauss syndrome
- Lupus
- Rheumatoid arthritis
- Polymyalgia rheumatica