Dexmedetomidine: Difference between revisions
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==Adult Dosing== | ==Adult Dosing== | ||
===[[ICU Sedation]]=== | |||
*1 mcg/kg over 10 minutes | |||
**Followed by 0.2 to 0.7 mcg/kg/hr | |||
===[[Procedural Sedation]]=== | |||
*1 mcg/kg over 10 minutes | |||
**Followed by 0.6 mcg/hr titrated to effect (generally 0.2 to 1 mcg/kg/hr) | |||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
Revision as of 16:36, 16 January 2019
General
- Type: Alpha-2 agonist; Sedative agents
- Dosage Forms:IV
- Common Trade Names: Precedex (US), Dexdor (European)
Adult Dosing
ICU Sedation
- 1 mcg/kg over 10 minutes
- Followed by 0.2 to 0.7 mcg/kg/hr
Procedural Sedation
- 1 mcg/kg over 10 minutes
- Followed by 0.6 mcg/hr titrated to effect (generally 0.2 to 1 mcg/kg/hr)
Pediatric Dosing
Post-Intubation Sedation
- Do not bolus
- Start at 0.2-0.4 mcg/kg/hour and titrate to a max of 1.4 mcg/kg/hour
- Recommended to start at 0.4 mcg/kg/hour for agitated patients
- Make changes every 15-20 minutes if not desired affect or sooner if patient is agitated
- May use with spot does of other medications like fentanyl and versed.
- If on fentanyl or versed drip already should be able to titrate the dose down.
Special Populations
- Pregnancy Rating: C
- Lactation: Unknown if excreted in milk. Exercise caution
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- Hypotension
- Bradycardia
- Apnea
Common
- Hypotension
- Bradycardia
- Dry mouth
Pharmacology
- Half-life: 2 hours
- Metabolism: Hepatic
- Excretion: Renal
- Mechanism of Action: Selective α-2 agonist
Comments
- Provides analgesia and anesthesia
- Hemodynamically neutral medication
- Provides sedation with maintenance of arousability, airway protection