Peramivir

Administration

• Type: Antiviral active against influenza
• Dosage Forms:
• Routes of Administration: IV
• Common Trade Names:

Adult Dosing

• Uncomplicated influenza: 600mg IV as single dose
• Influenza requiring hospitalization: 600mg IV daily or 300mg IV BID for 5-10 days

Pediatric Dosing

Safety/efficacy not established

Special Populations

• Pregnancy Rating: C
• Lactation risk: Infant risk cannot be ruled out
• Renal dosing
  • CrCl 30-50: 150-200mg IV daily
  • CrCl 10-30: 100mg IV daily
  • CrCl <10: 100 mg IV on day 1, followed by 15 mg IV daily on subsequent days
• Hepatic dosing: not defined

Contraindications

• Allergy to class/drug

Adverse Reactions

Serious

• SJS
• Anaphylaxis
• Abnormal behavior, hallucinations

Common

• Diarrhea

Pharmacology

• Half-life: 20h
• Metabolism:
• Excretion: Mostly renal

Mechanism of Action

• Inhibits neuraminidase activity of influenza A and B

See Also

• Influenza