Sarcoidosis: Difference between revisions
ClaireLewis (talk | contribs) No edit summary |
ClaireLewis (talk | contribs) No edit summary |
||
| Line 14: | Line 14: | ||
**[[Cough]] | **[[Cough]] | ||
**[[Pulmonary hypertension]] | **[[Pulmonary hypertension]] | ||
**Pulmonary abscesses/[[empyema]] | **[[lung abscess|Pulmonary abscesses]]/[[empyema]] | ||
**[[Pneumothorax]] | **[[Pneumothorax]] | ||
*Erythema nodosum and other skin lesions | *[[Erythema nodosum]] and other skin lesions | ||
*Fatigue | *Fatigue | ||
*Weight loss | *Weight loss | ||
* | *[[Arthralgia]]s | ||
*Cardiopulmonary | *Cardiopulmonary | ||
**[[Restrictive cardiomyopathy]] | **[[Restrictive cardiomyopathy]] | ||
** | **[[Arrhythmias]] due to conduction disturbance | ||
*Endocrine | *Endocrine | ||
**[[Hypercalcemia]] | **[[Hypercalcemia]] | ||
| Line 28: | Line 28: | ||
**[[Adrenal insufficiency]] | **[[Adrenal insufficiency]] | ||
*Ocular | *Ocular | ||
**Dacryoadenitis (lacrimal duct inflammation) | **[[Dacryoadenitis]] (lacrimal duct inflammation) | ||
**Optic neuritis | **[[Optic neuritis]] | ||
**Iritis | **[[Iritis]] | ||
Revision as of 18:20, 13 October 2019
Background
- Abnormal collection of inflammatory cells (granulomas) throughout the body.
- Most common location for granulomas to occur are the lung, skin, heart, and brain.
- Exact cause unknown - thought to be related to an immune reaction to a prior insult such as infection or chemical exposure earlier in life.
- Do not confuse with infectious granulomatous processes such as tuberculosis.
Clinical Features
Depend on location of granulomata. May be entirely asymptomatic.
- Respiratory
- Due to pulmonary granulomata
- Shortness of breath
- Cough
- Pulmonary hypertension
- Pulmonary abscesses/empyema
- Pneumothorax
- Erythema nodosum and other skin lesions
- Fatigue
- Weight loss
- Arthralgias
- Cardiopulmonary
- Restrictive cardiomyopathy
- Arrhythmias due to conduction disturbance
- Endocrine
- Ocular
- Dacryoadenitis (lacrimal duct inflammation)
- Optic neuritis
- Iritis
Differential Diagnosis
- Malignancy
- Tuberculosis
- Coccidioidomycosis
- Histiocytosis X
- Wegener's granulomatosis
- Churg-Strauss syndrome
- Lupus
- Rheumatoid arthritis
- Polymyalgia rheumatica
Workup
- Definitive initial diagnosis unlikely to be made in ED, but may be suggested by typical granulomatous lesions seen on CT or other imaging in setting of appropriate clinical context
- Evaluate for complications/alternative diagnoses of presenting symptoms
Management
- Corticosteroids
- Treat complications
Disposition
- Dependant on presentation