Fever of unknown origin

DDX

1. Infectious disease (22%)
   1. EBV
   2. UTI
   3. Enterovirus
   4. Lyme
   5. Cat-scratch disease
   6. Osteomyelitis
   7. Psittacosis
   8. Rheumatic fever
   9. Crohn's
   10. Bacterial meningitis
2. Autoimmune (6%)
   1. JRA
   2. SLE
   3. PAN
3. Malignancy (2%)
   1. Leukemia
   2. Lymphoma
4. Drug-induced fever (2%)
5. Factitious (2%)
6. No Etiology (67%)

Workup

Phase 1

1. CBC
2. ESR
3. TB test
4. MonoSpot
5. CXR
6. BCx
7. ASLO
8. ANA
9. HIV

Phase 2

1. LP
2. BCx again
3. Sinus/mastoid x-ray
4. Ophtho exam for iridocyclits
5. CMV, Toxo, Hep A/B, Tularemia, Brucellosis, Leptospirosis, Salmonellosis
6. LFTs

Phase 3

1. Abd U/S
2. Abd CT
3. Gallium/Indium scanning
4. UGI series c sbft
5. Bone marrow
6. Technetium bone scan

See Also

• Fever