Malignant bone tumors: Difference between revisions
Mtjordan91 (talk | contribs) (Created page with "==Background== ==Clinical Features== ==Differential Diagnosis<ref>Niederhuber, John E., et al. “Sarcomas.” Abeloff's Clinical Oncology E-Book. Elsevier Health Sciences...") |
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| align="center" style="background:#f0f0f0;"|'''Clinical Importance''' | | align="center" style="background:#f0f0f0;"|'''Clinical Importance''' | ||
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| Adamantinoma||Bone pain over anterior tibia in adolescent or young adult||Soap Bubble osteolytic appearance on plain radiograph||Metastasis to lungs | | Adamantinoma||Bone pain over anterior tibia in adolescent or young adult||Soap Bubble osteolytic appearance on plain radiograph||"Metastasis to lungs | ||
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| May need amputation" | |||
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| Chordoma||Constant pain if in sacrum | | Chordoma||"Constant pain if in sacrum | ||
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| Neurological deficits if at base of skull, most commonly in cranial nerves to the eye "||Plain radiograph will show a destructive bone lesion often with an associated soft tissue mass||"Slow growing but locally aggressive | |||
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| Metastasis is uncommon, local recurrence is much more likely" | |||
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| Fibrosarcoma and Undifferentiated pleomorphic sarcoma||Similar to osteosarcoma except malignant fibroblasts but less common||Most common in distal femur and proximal tibia||Similar outcome to osteosarcoma | | Fibrosarcoma and Undifferentiated pleomorphic sarcoma||Similar to osteosarcoma except malignant fibroblasts but less common||Most common in distal femur and proximal tibia||Similar outcome to osteosarcoma | ||
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| Primary bone lymphoma||Adult > 40 years of age with bone pain or pathologic fracture||Bone destruction | | Primary bone lymphoma||Adult > 40 years of age with bone pain or pathologic fracture||"Bone destruction | ||
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| Soft tissue mass"||5 year survival is greater than 50% with radiation and chemotherapy | |||
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==Evaluation== | ==Evaluation== | ||
Revision as of 23:05, 21 November 2019
Background
Clinical Features
Differential Diagnosis[1]
| Name | Presentation | Radiograph Findings | Clinical Importance |
| Adamantinoma | Bone pain over anterior tibia in adolescent or young adult | Soap Bubble osteolytic appearance on plain radiograph | "Metastasis to lungs |
| May need amputation" | |||
| Chordoma | "Constant pain if in sacrum | ||
| Neurological deficits if at base of skull, most commonly in cranial nerves to the eye " | Plain radiograph will show a destructive bone lesion often with an associated soft tissue mass | "Slow growing but locally aggressive | |
| Metastasis is uncommon, local recurrence is much more likely" | |||
| Fibrosarcoma and Undifferentiated pleomorphic sarcoma | Similar to osteosarcoma except malignant fibroblasts but less common | Most common in distal femur and proximal tibia | Similar outcome to osteosarcoma |
| Primary bone lymphoma | Adult > 40 years of age with bone pain or pathologic fracture | "Bone destruction | |
| Soft tissue mass" | 5 year survival is greater than 50% with radiation and chemotherapy |
Evaluation
Management
Disposition
References
- ↑ Niederhuber, John E., et al. “Sarcomas.” Abeloff's Clinical Oncology E-Book. Elsevier Health Sciences, 2019, pp. 1604 – 1654.e8.