Simethicone

Administration

• Dosage Forms: Cap: 125mg, 180mg; Chew: 80mg, 125mg; Susp: 40mg per 0.6mL
• Routes of Administration: Oral
• Common Trade Names: Gas-X

Adult Dosing

• 40-360 mg PO QID prn flatulence
  • Max: 500mg/day

Pediatric Dosing

• <2 years old
  • 20mg PO QID prn
    • Max: 240mg/day
• 2-12 years old
  • 40mg PO QID prn
    • Max: 480 mg/day
• >12 years old
  • Use adult dosing

Special Populations

Pregnancy Rating

• May use during pregnancy

Lactation risk

• No human data available

Renal Dosing

• Adult: N/A
• Pediatric: N/A

Hepatic Dosing

• Adult: N/A
• Pediatric: N/A

Contraindications

• Allergy to class/drug
• Intestinal perforation
• GI Obstruction

Adverse Reactions

Serious

• None reported

Common

• Diarrhea
• Nausea

Pharmacology

• Half-life: Unknown
• Metabolism: None
• Excretion: Feces (100% unchanged)

Mechanism of Action

• Alters gas bubble surface tension