Acrodermatitis enteropathica: Difference between revisions
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Revision as of 22:09, 14 December 2022
Background
- Disorder of zinc metabolism (either congenital mutation, abnormal zinc characteristics in mother's breast milk, or due to surgery affecting upper GI tract) that leads to effective zinc deficiency
Clinical Features
- Diarrhea, steatorrhea
- Irritation/inflammation of skin around body openings (e.g. mouth, anus, eyes, hands/feet)
- Typically vesiculobullous initially, then dry and resemble psoriasis rash
- Nails may become abnormal
- Alopecia
- Conjunctivitis
Differential Diagnosis
Evaluation
- Serum zinc level typically low
- Reduced serum alkaline phosphatase levels often supportive evidence for zinc deficiency, as zinc is a cofactor for alkaline phosphatase activity[1]
Management
- Zinc sulfate supplementation (13.2 mg/kg/day, totaling ~3mg/kg/day of elemental zinc)
- Monitor zinc levels every 4-6 months
Disposition
See Also
External Links
References
- ↑ Kiliç I, Ozalp I, Coŝkun T, Tokatli A, Emre S, Saldamli I, Köksel H, Ozboy O. The effect of zinc-supplemented bread consumption on school children with asymptomatic zinc deficiency. J Pediatr Gastroenterol Nutr. 1998 Feb;26(2):167-71. doi: 10.1097/00005176-199802000-00008. PMID: 9481631.