Praziquantel: Difference between revisions

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(Replace manual dosing with dynamic SMW tables (Adult + Pediatric))
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==Adult Dosing==
==Adult Dosing==
*Schistosomiasis: 20mg/kg PO tid x1 day
===Indications by Disease===
**Separate doses by 4-6h
{{#ask: [[Has DrugName::Praziquantel]] [[Has Population::Adult]]
**Give with food
|?Treats disease=Disease
**Do not crush/chew
|?Has Dose=Dose
 
|?Has Context=Context
*Liver flukes: 25mg/kg PO tid x1 day
|format=table
**Separate doses by 4-6h
|limit=50
 
|mainlabel=-
*Cysticercosis: 50mg/kg/day PO divided q8h x14 days
|headers=show
**Off label use
|sort=Treats disease
 
}}
*Tapeworms: 5-25mg/kg PO x1
**Off label use


==Pediatric Dosing==
==Pediatric Dosing==
===Only for children> 4 y/o===
===Indications by Disease===
*Schistosomiasis: 20mg/kg PO bid-tid x1 day
{{#ask: [[Has DrugName::Praziquantel]] [[Has Population::Pediatric]]
 
|?Treats disease=Disease
*Liver flukes: 25mg/kg PO tid x1-2 days
|?Has Dose=Dose
 
|?Has Context=Context
*Cysticercosis: 50mg/kg/day PO divided q8h x14 days
|format=table
**Off label use
|limit=50
 
|mainlabel=-
*Tape worms: 5-25mg/kg PO x1
|headers=show
**Off label use
|sort=Treats disease
}}


==Special Populations==
==Special Populations==

Revision as of 01:53, 20 March 2026

Administration

  • Type: Antiparasitic, anthelmintic
  • Dosage Forms: 600
  • Routes of Administration: Oral
  • Common Trade Names: Biltricide

Adult Dosing

Indications by Disease

Pediatric Dosing

Indications by Disease

Special Populations

  • Pregnancy Risk Factor B

Renal Dosing

  • No renal dosing defined

Hepatic Dosing

  • Caution advised with Child-Pugh Class B or C

Contraindications

  • Allergy to class/drug
  • ocular schistosomiasis
  • ocular cysticercosis
  • CNS lesions
  • seizure history

Adverse Reactions

Serious

  • Generalized hypersensitivity reaction
  • polyserositis
  • arrhythmias
  • bradycardia
  • ventricular fibrillation
  • AV block
  • diarrhea, bloody
  • seizures
  • Jarisch-Herxheimer reaction

Common

  • malaise
  • headache
  • dizziness
  • abdominal pain/nausea and vomiting

Pharmacology

  • Half-life: 1-1.5hr
  • Metabolism: CYP450
  • Excretion: Urine

Mechanism of Action

  • Increases cell membrane permeability

Comments

See Also

References

<Epocrates, UpToDate>