Pyrantel Pamoate: Difference between revisions

(Replace manual dosing with dynamic SMW tables)
(Restore original dosing content alongside dynamic SMW tables)
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==Administration==
==General==
*Type: [[Antiparasitic]]
*AKA: aloprostadil
*Dosage Forms:
*Type: smooth muscle relaxer, vasodilator
*Routes of Administration: Oral
*Dosage Forms: intravenous, penile injection, penile suppository
*Common Trade Names:
*Common Trade Names: [https://alprostadil.org Alprostadil], Prostin VR, Caverject, Muse, Edex
*Uses: maintenance of [[patent ductus arteriosus]] in neonates with duct-dependent congenital heart defects; treatment of erectile dysfunction in adults


==Adult Dosing==
==Adult Dosing==
==Pediatric Dosing<ref> Donofrio MT, Moon-Grady AJ, Hornberger LK, Copel JA, Sklansky MS, Abuhamad A, Cuneo BF, Huhta JC, Jonas RA, Krishnan A, Lacey S, Lee W, Michelfelder EC Sr, Rempel GR, Silverman NH, Spray TL, Strasburger JF, Tworetzky W, Rychik J. Diagnosis and treatment of fetal cardiac disease: a scientific statement from the American Heart Association. American Heart Association Adults With Congenital Heart Disease Joint Committee of the Council on Cardiovascular Disease in the Young and Council on Clinical Cardiology, Council on Cardiovascular Surgery and Anesthesia, and Council on Cardiovascular and Stroke Nursing.Circulation. 2014 May 27;129(21):2183-242. doi: 10.1161/01.cir.0000437597.44550.5d. Epub 2014 Apr 24.</ref>==
*Start infusion at 0.05 mcg/kg/min IV
**Titrate to 0.1 mcg/kg/min as tolerated, monitoring for hypotension (and apnea)
===Indications by Disease===
===Indications by Disease===
{{#ask: [[Has DrugName::Pyrantel Pamoate]] [[Has Population::Adult]]
{{#ask: [[Has DrugName::Pyrantel Pamoate]] [[Has Population::Adult]]
|?Treats disease=Disease
|?Treats disease=Disease
|?Has Dose=Dose
|?Has Dose=Dose
|?Has Context=Context
|?Has Context=Context
|format=table
|format=table
|limit=50
|limit=50
|mainlabel=-
|mainlabel=-
|headers=show
|headers=show
|sort=Treats disease
|sort=Treats disease
}}
}}


==Pediatric Dosing==
==Pediatric Dosing==
===Indications by Disease===
===Indications by Disease===
{{#ask: [[Has DrugName::Pyrantel Pamoate]] [[Has Population::Pediatric]]
{{#ask: [[Has DrugName::Pyrantel Pamoate]] [[Has Population::Pediatric]]
|?Treats disease=Disease
|?Treats disease=Disease
|?Has Dose=Dose
|?Has Dose=Dose
|?Has Context=Context
|?Has Context=Context
|format=table
|format=table
|limit=50
|limit=50
|mainlabel=-
|mainlabel=-
|headers=show
|headers=show
|sort=Treats disease
|sort=Treats disease
}}
}}


==Special Populations==
==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C
*[[Lactation risk categories|Lactation risk]]: Infant risk cannot be ruled out
*Lactation: infant risk cannot be ruled out
*Renal dosing:
*Renal Dosing
*Hepatic dosing:
**Adult
**Pediatric
*Hepatic Dosing
**Adult
**Pediatric


==Contraindications==
==Contraindications==
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==Adverse Reactions==
==Adverse Reactions==
===Serious===
*Beware of three common side effects that may require further resuscitation<ref>Martin RJ et al. Pathophysiologic Mechanisms Underlying Apnea of Prematurity. NeoReviews Vol.3 No.4 April 2002.</ref><ref>Segar JL. Protocol for Use of Prostaglandin E. University of Iowa Stead Family Children's Hospital. Accessed Dec 2016. https://uichildrens.org/health-library/protocol-use-prostaglandin-e?id=234424</ref>:
 
**Apnea (12%), which requires respiratory monitoring with ETCO2 capnography, potential mechanical ventilation, and/or ALS/PALS transport if needing transfer to higher level of care
===Common===
**Peripheral flushing with or without hypotension (10%), which requires fluid resuscitation
*Nausea/vomiting, diarrhea
**[[Fever]] (14%)
*Headache, dizziness, somnolence
*Others:
**[[Hypotension]]
**[[Bradycardia]]
**[[Seizures]]


==Pharmacology==
==Pharmacology==
*Half-life:  
*Half-life: 5-10m
*Metabolism:  
*Metabolism: Lung
*Excretion: Fecal
*Excretion: Renal
 
*Mechanism of Action: synthetic of endogenous prostaglandin
==Mechanism of Action==
*depolarizing neuromuscular blocking agent, causes spastic paralysis in the worms


==Comments==
==Comments==
*Indicated to treat infection with [[enterobius]], [[ascaris]], and other similar worms
*Cyanotic neonates with ductal-dependent lesions typically respond within 10-15 minutes, but may not show response until several hours after the start of infusion.


==See Also==
==See Also==
*[[Parasitic diseases]]
*[[Tetralogy of fallot]]


==References==
==References==
<references/>
<references/>
[[Category:Pharmacology]]
[[Category:Pharmacology]]
[[Category:ID]]
[[Category:Pediatrics]]
[[Category:Cardiology]]

Revision as of 02:39, 20 March 2026

General

  • AKA: aloprostadil
  • Type: smooth muscle relaxer, vasodilator
  • Dosage Forms: intravenous, penile injection, penile suppository
  • Common Trade Names: Alprostadil, Prostin VR, Caverject, Muse, Edex
  • Uses: maintenance of patent ductus arteriosus in neonates with duct-dependent congenital heart defects; treatment of erectile dysfunction in adults

Adult Dosing

Pediatric Dosing[1]

  • Start infusion at 0.05 mcg/kg/min IV
    • Titrate to 0.1 mcg/kg/min as tolerated, monitoring for hypotension (and apnea)


Indications by Disease

DiseaseDoseContext
Enterobius11mg/kg (max 1g) PO once then repeat in 2 weeksAdult first choice for pregnant

Pediatric Dosing

Indications by Disease

Special Populations

  • Pregnancy Rating: C
  • Lactation: infant risk cannot be ruled out
  • Renal Dosing
    • Adult
    • Pediatric
  • Hepatic Dosing
    • Adult
    • Pediatric

Contraindications

  • Allergy to class/drug

Adverse Reactions

  • Beware of three common side effects that may require further resuscitation[2][3]:
    • Apnea (12%), which requires respiratory monitoring with ETCO2 capnography, potential mechanical ventilation, and/or ALS/PALS transport if needing transfer to higher level of care
    • Peripheral flushing with or without hypotension (10%), which requires fluid resuscitation
    • Fever (14%)
  • Others:

Pharmacology

  • Half-life: 5-10m
  • Metabolism: Lung
  • Excretion: Renal
  • Mechanism of Action: synthetic of endogenous prostaglandin

Comments

  • Cyanotic neonates with ductal-dependent lesions typically respond within 10-15 minutes, but may not show response until several hours after the start of infusion.

See Also

References

  1. ↑ Donofrio MT, Moon-Grady AJ, Hornberger LK, Copel JA, Sklansky MS, Abuhamad A, Cuneo BF, Huhta JC, Jonas RA, Krishnan A, Lacey S, Lee W, Michelfelder EC Sr, Rempel GR, Silverman NH, Spray TL, Strasburger JF, Tworetzky W, Rychik J. Diagnosis and treatment of fetal cardiac disease: a scientific statement from the American Heart Association. American Heart Association Adults With Congenital Heart Disease Joint Committee of the Council on Cardiovascular Disease in the Young and Council on Clinical Cardiology, Council on Cardiovascular Surgery and Anesthesia, and Council on Cardiovascular and Stroke Nursing.Circulation. 2014 May 27;129(21):2183-242. doi: 10.1161/01.cir.0000437597.44550.5d. Epub 2014 Apr 24.
  2. ↑ Martin RJ et al. Pathophysiologic Mechanisms Underlying Apnea of Prematurity. NeoReviews Vol.3 No.4 April 2002.
  3. ↑ Segar JL. Protocol for Use of Prostaglandin E. University of Iowa Stead Family Children's Hospital. Accessed Dec 2016. https://uichildrens.org/health-library/protocol-use-prostaglandin-e?id=234424
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