Template:Malaria antibiotics: Difference between revisions
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===Suppression=== | ===Suppression=== | ||
*{{AntibioticDose|drug=Dapsone|dose=100mg PO weekly|context=Suppression|disease=Malaria|population=Adult}} | *{{AntibioticDose|drug=Dapsone|dose=100mg PO weekly|context=Suppression|disease=Malaria|population=Adult}} | ||
===Quinine-based Regimens=== | |||
====Adult==== | |||
*{{AntibioticDose|drug=Quinine|dose=648mg PO q8h x 7 days|context=Uncomplicated malaria, use with doxycycline or clindamycin|disease=Malaria|population=Adult}} | |||
====Pediatric==== | |||
*{{AntibioticDose|drug=Quinine|dose=30mg/kg/day PO q8h x 3-7 days (Max: 648mg/dose)|context=Uncomplicated malaria, use with clindamycin|disease=Malaria|population=Pediatric}} | |||
Latest revision as of 12:16, 20 March 2026
- For specific dosing see the CDC Recommendations or call the Malaria CDC Hotline(855) 856-4713
Uncomplicated Malaria
- Uncomplicated:
- No evidence of organ dysfunction
- Parasitemia <5%
- Able to tolerate PO
- Hospitalize:
- Severe clinical manifestations in non-immune host for P. falciparum or P. knowlesi
- Report to state health department
- For non-pregnant patients (3 day course)
- Artemether + lumefantrine
- Artesunate + amodiaquine
- Artesunate + mefloquine
- Dihydroartemisinin + piperaquine
- Artesunate + sulfadoxine–pyrimethamine (SP)
- For pregnant (1st trimester)
- Quinine + clindamycin x 7 days
- Additional considerations
- Avoid artesunate + SP in HIV/AIDS patients taking co-trimoxazole
- Avoid artesunate + amodiaquine in HIV/AIDS patients taking efavirenz or zidovudine
- P. vivax and P. ovale have dormant hypnozoites in the liver which require treatment with primaquine phosphate for complete eradication
Severe Malaria
- Do not delay treatment in the unstable patient if strong suspicion for malaria as initial smear may be falsely negative
- Treatment (IV for ≥24 hours then 3 days PO course)
- Artesunate (IV)
- Clears malaria faster than quinine
- Distributed only through CDC
- Quinidine (IV) also appropriate choice; more available in US
- Artesunate (IV)
Prophylaxis
- Doxycycline 100mg PO daily
- Doxycycline 2.2 mg/kg/day PO daily (max 100mg/day), >8 years old
Suppression
- Dapsone 100mg PO weekly
Quinine-based Regimens
Adult
- Quinine 648mg PO q8h x 7 days
Pediatric
- Quinine 30mg/kg/day PO q8h x 3-7 days (Max: 648mg/dose)