Phentolamine: Difference between revisions
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==Mechanism of Action== | ==Mechanism of Action== | ||
*[[alpha 1 Blocker|α antagonist]] | *[[alpha 1 Blocker|α antagonist]] | ||
==Indications by Condition== | |||
''The following table is automatically generated from disease/condition pages across WikEM.'' | |||
{{#ask:[[Has DrugName::Phentolamine]] | |||
|?Has Indication=Indication | |||
|?Has Dose=Dose | |||
|?Has Context=Context | |||
|?Has Route=Route | |||
|?Has Population=Population | |||
|format=broadtable | |||
|headers=plain | |||
|mainlabel=- | |||
|sort=Has Indication | |||
|limit=50 | |||
}} | |||
==See Also== | ==See Also== | ||
Revision as of 18:20, 20 March 2026
Administration
- Type: Alpha 1 Blocker; Antidote, Extravasation; Antihypertensive
- Routes of Administration: IV, IM
- Common Trade Names: OraVerse
Adult Dosing
- Pheochromocytomectomy adjunct: 5mg IM/IV q2-4h PRN
- Start: 1-2h preop
- Extravasation (norepinephrine-associated): 5-10mg injected into affected area x1
- Start: within 12h of extravasation
- Hypertensive crisis: 5mg IM/IV q2-4h PRN
Pediatric Dosing
- Pheochromocytomectomy adjunct: 1mg IM/IV q2-4h PRN
- Start: 1-2h preop
Special Populations
- Pregnancy Risk Factor: C
Renal Dosing
- No dosing adjustments
Hepatic Dosing
- No dosing adjustments
Contraindications
- Hypersensitivity to phentolamine or components
- MI
- CAD
- Angina
- Caution if PUD
Adverse Reactions
Serious
- MI
- stroke
- hypotension, severe
- arrhythmias
- PUD
- priapism
Common
- tachycardia
- weakness
- dizziness
- flushing
- orthostatic hypotension
- nasal congestion
- nausea
- vomiting
- diarrhea
Pharmacology
- Half-life: 19 minutes
- Metabolism: Urine
- Excretion: CYP450
Mechanism of Action
Indications by Condition
The following table is automatically generated from disease/condition pages across WikEM.
| Indication | Dose | Context | Route | Population |
|---|---|---|---|---|
| Cocaine toxicity | 2.5-5mg IV | Direct alpha-antagonist for refractory hypertension | IV | Adult |
| Hypertensive emergency | 5-15 mg IV | Pheochromocytoma crisis | IV | Adult |
| Monoamine oxidase inhibitor toxicity | 2.5-5mg IV bolus q10-15min; or infusion 0.2-0.5mg/min | Hypertension, short-acting agent | IV | Adult |
| Pheochromocytoma | 5 mg q2-4hr PRN | Alpha-blocker for hypertensive crisis | IV/IM | Adult |
See Also
References
<Epocrates, UpToDate>