Baclofen toxicity: Difference between revisions
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==Toxicity== | ==Toxicity== | ||
* | *N/V | ||
*Drowziness, dizziness | |||
*Seizures, delirium, AMS, coma | |||
*Bradycardia, hypotension OR HTN, respiratory compromise | |||
*Hypothermia | |||
==Management== | ==Management== | ||
Revision as of 23:55, 16 July 2015
Background
- Indications include MS, muscle spasticity pain
- GABAb receptor agonist
Toxicity
- N/V
- Drowziness, dizziness
- Seizures, delirium, AMS, coma
- Bradycardia, hypotension OR HTN, respiratory compromise
- Hypothermia
Management
- Diagnosis of exclusion
- Activated charcoal for recent ingestion
- Supportive care:
- IV fluids, respiratory care
- Benzodiazepines for seizures
- Hemodialysis for very severe toxicity
References
- Jung, M. “Baclofen Overdoses”. Maryland Poison Center, University of Maryland School of Pharmacy. www.mdpoison.com Accessed April 29th, 2014.
- Nicola Y Leung, Ian M Whyte, Geoffrey K Isbister Baclofen overdose: defining the spectrum of toxicity. Emerg Med Australas: 2006, 18(1);77-82