Abdominal Pain Differential (Comprehensive)

• Please add and edit to expand, to include even rare and unlikely DDx
• In no particular order

• As differs from this list: Abdominal pain

RUQ

Cholelithiasis, acute cholecystitis, cholangitis, biliary colic, acute hepatitis, PUD/perforated duodenal ulcer, right lower lobe pneumonia, pyelonephritis, pyonephrosis/renal abscess, psoas abscess, nephrolithiasis

LUQ

Gastritis, PUD, splenic abscess/rupture/infarct, left lower lobe pneumonia, pyelonephritis, nephrolithiasis

Epigastric

Gastritis, dyspepsia, pancreatitis, AMI, GERD, hiatal hernia, aortic dissection, pulmonary embolism

Lower

Bladder distension, UTI

RLQ

Appendicitis, Meckel's, ectopic pregnancy, ovarian torsion, mittelschmerz, PID, TOA, urolithiasis, psoas abscess

LLQ

Diverticulitis, ectopic pregnancy, ovarian torsion, mittelschmerz, PID, TOA, urolithiasis, psoas abscess

Diffuse or Nonspecific

Early appendicitis, mesenteric ischemia, ischemic colitis, gastroenteritis, constipation, opioid bowel syndrome, intussusception, volvulus, peritonitis, AAA, SBO, LBO, spontaneous bacterial peritonitis, IBD, colitis, C. diff, infectious diarrhea, DKA, sickle cell crisis/complications, hyperparathyroidism, mesenteric venous thrombosis, endometriosis, GI malignancy, IBS, lactose intolerance, psychogenic/somatization, fibromyalgia

Female

PID, adnexal pathology, endometriosis, ectopic pregnancy, endometritis, leiomyoma, Mittelsmertz, Fitz-Hugh-Curtis

Rare

Aortic dissection, hemophilia (hematoma of bowel walls), high dose steroids (bowel perforation), celiac artery compression, SMA syndrome, Nutcracker syndrome, painful rib syndrome, wandering spleen, abdominal wall pain, abdominal migraine, mesenteric lymphadenitis, eosinophilic gastroenteritis, epiploid appendagitis, abdominal compartment syndrome, familial Mediterranean fever, hereditary angioedema, ACEi angioedema, acute intermittent porphyria, lead toxicity, vasculitis leading to mesenteric ischemia, mesenteric panniculitis