Hypersensitivity reaction: Difference between revisions
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! Type !! Mechanism !! Example | ! Type !! Mechanism !! Example | ||
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| I: Allergy, Immediate || IgE-mediated degranulation of mast cells and basophils; usually happens after a first exposure which causes sensitization || Urticaria, anaphylaxis, angioedema | | I: Allergy, Immediate || IgE-mediated degranulation of mast cells and basophils; usually happens after a first exposure which causes sensitization || [[Urticaria]], [[anaphylaxis]], [[angioedema]] | ||
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| II: Cytotoxic, Antibody Dependant || IgG or IgM antibodies react with cell antigens with resultant complement activation || Myasthenia gravis, goodpasture syndrome, erythroblastalis fetalis, AI hemolytic anemia, Graves disease | | II: Cytotoxic, Antibody Dependant || IgG or IgM antibodies react with cell antigens with resultant complement activation || [[Myasthenia gravis]], [[goodpasture syndrome]], erythroblastalis fetalis, AI hemolytic anemia, Graves disease | ||
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| III: Immune Complex || IgG immune complex deposition and subsequent complement activation || Serum sickness, RA, SLE, post-strep glomerularnephritis | | III: Immune Complex || IgG immune complex deposition and subsequent complement activation || [[Serum sickness]], RA, [[SLE]], [[post-strep glomerularnephritis]] | ||
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| IV: Cell-mediated, Delayed || Activated T cells against cell surface antigens || TB skin test, chronic transplant rejection, contact dermatitis | | IV: Cell-mediated, Delayed || Activated T cells against cell surface antigens || TB skin test, chronic transplant rejection, contact dermatitis | ||
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==See Also== | ==See Also== | ||
*[[Acute allergic reaction]] | *[[Acute allergic reaction]] | ||
*[[Contact dermatitis]] | *[[Contact dermatitis]] | ||
==References== | ==References== | ||
<references/> | <references/> | ||
Revision as of 04:08, 21 October 2015
Background
- Uncomfortable, damaging, and sometimes fatal reactions produced by the normal immune system including allergies and autoimmunity.
Clinical Features
| Type | Mechanism | Example |
|---|---|---|
| I: Allergy, Immediate | IgE-mediated degranulation of mast cells and basophils; usually happens after a first exposure which causes sensitization | Urticaria, anaphylaxis, angioedema |
| II: Cytotoxic, Antibody Dependant | IgG or IgM antibodies react with cell antigens with resultant complement activation | Myasthenia gravis, goodpasture syndrome, erythroblastalis fetalis, AI hemolytic anemia, Graves disease |
| III: Immune Complex | IgG immune complex deposition and subsequent complement activation | Serum sickness, RA, SLE, post-strep glomerularnephritis |
| IV: Cell-mediated, Delayed | Activated T cells against cell surface antigens | TB skin test, chronic transplant rejection, contact dermatitis |