Topiramate: Difference between revisions
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==Adult Dosing== | ==Adult Dosing== | ||
===Partial Seizures=== | |||
*monotherapy | |||
**Dose: 200 mg PO bid; Start: 25 mg PO bid x1wk, incr. by 50 mg/day qwk until 100 mg PO bid, then incr. by 100 mg/day qwk; Info: doses >400 mg/day rarely more effective | |||
* adjunct therapy | |||
**Dose: 100-200 mg PO bid; Start: 25 mg PO qd-bid x1wk, incr. by 25-50 mg/day qwk; Info: doses >400 mg/day rarely more effective | |||
===seizures, primary generalized tonic clonic=== | |||
*monotherapy | |||
**Dose: 200 mg PO bid; Start: 25 mg PO bid x1wk, incr. by 50 mg/day qwk until 100 mg PO bid, then incr. by 100 mg/day qwk; Info: doses >400 mg/day rarely more effective | |||
*adjunct therapy | |||
**Dose: 200 mg PO bid; Start: 25 mg PO qd-bid x1wk, incr. by 25-50 mg/day qwk; Info: doses >400 mg/day rarely more effective | |||
===Seizures, Lennox-Gastaut=== | |||
*adjunct therapy | |||
**Dose: 100-200 mg PO bid; Start: 25 mg PO qd-bid x1wk, incr. by 25-50 mg/day qwk; Info: doses >400 mg/day rarely more effective | |||
===Migraine headache, prophylaxis=== | |||
*50 mg PO bid | |||
**Start: 25 mg PO qhs x1wk, incr. by 25 mg/day qwk; Max: 200 mg/day | |||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
Revision as of 02:02, 11 February 2016
Administration
- Type: anti epileptic
- Dosage Forms: 25,50,100,200 tabs; 15,25 caps
- Routes of Administration: PO
- Common Trade Names: Topamax
Adult Dosing
Partial Seizures
- monotherapy
- Dose: 200 mg PO bid; Start: 25 mg PO bid x1wk, incr. by 50 mg/day qwk until 100 mg PO bid, then incr. by 100 mg/day qwk; Info: doses >400 mg/day rarely more effective
- adjunct therapy
- Dose: 100-200 mg PO bid; Start: 25 mg PO qd-bid x1wk, incr. by 25-50 mg/day qwk; Info: doses >400 mg/day rarely more effective
seizures, primary generalized tonic clonic
- monotherapy
- Dose: 200 mg PO bid; Start: 25 mg PO bid x1wk, incr. by 50 mg/day qwk until 100 mg PO bid, then incr. by 100 mg/day qwk; Info: doses >400 mg/day rarely more effective
- adjunct therapy
- Dose: 200 mg PO bid; Start: 25 mg PO qd-bid x1wk, incr. by 25-50 mg/day qwk; Info: doses >400 mg/day rarely more effective
Seizures, Lennox-Gastaut
- adjunct therapy
- Dose: 100-200 mg PO bid; Start: 25 mg PO qd-bid x1wk, incr. by 25-50 mg/day qwk; Info: doses >400 mg/day rarely more effective
Migraine headache, prophylaxis
- 50 mg PO bid
- Start: 25 mg PO qhs x1wk, incr. by 25 mg/day qwk; Max: 200 mg/day
Pediatric Dosing
Special Populations
Renal Dosing
- Adult:
- Pediatric:
Hepatic Dosing
- Adult:
- Pediatric:
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
Common
Pharmacology
- Half-life:
- Metabolism:
- Excretion: