Antidotes: Difference between revisions
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| '''ANTIDOTE''' | | '''ANTIDOTE''' | ||
|- | |- | ||
| [[ | | [[Acetaminophen]] | ||
| | | | ||
[[N-Acetylcysteine]] | |||
*150mg/kg IV load over 60min; followed by 50mg/kg IV over 4hr and then 100mg/kg IV over 16hr | |||
|- | |- | ||
| [[Anticholinergic toxicity|Anticholinergics]] | | [[Anticholinergic toxicity|Anticholinergics]] | ||
| Physostigmine | | [[Physostigmine]] | ||
|- | |- | ||
| [[Arsenic]] | | [[Arsenic]] | ||
| Dimercaprol (BAL) | | [[Dimercaprol]] (BAL) | ||
|- | |- | ||
| [[Benzodiazepines]] | | [[Benzodiazepines]] | ||
| | | | ||
[[Flumazenil]] | |||
*Adult: 0.2mg IV | |||
*Peds: 0.01mg/kg IV | |||
|- | |- | ||
| [[Beta-Blocker Toxicity|Beta blockers]] | | [[Beta-Blocker Toxicity|Beta blockers]] | ||
| | | | ||
[[Glucagon]] | [[Glucagon]] | ||
*Adult: 3-10mg IV | |||
Adult: 3-10mg IV | *Peds: 50-150mcg/kg IV | ||
Peds: 50-150mcg/kg IV | |||
|- | |- | ||
| | | [[Calcium Channel Blocker Toxicity|Ca channel blockers]] | ||
[[Calcium Channel Blocker Toxicity|Ca channel blockers]] | |||
| | | | ||
[[Calcium chloride]] 10% | [[Calcium chloride]] 10% | ||
**Adult: 10 mL IV | |||
Adult: 10 mL IV | **Peds: 0.2-0.25 mL/kg IV | ||
Peds: 0.2-0.25 mL/kg IV | |||
High Dose Insulin (1 unit/kg/hr) | High Dose Insulin (1 unit/kg/hr) | ||
|- | |- | ||
| | | [[Clonidine Toxicity|Clonidine]] | ||
[[Clonidine Toxicity|Clonidine]] | |||
| | | | ||
[[Naloxone]] | [[Naloxone]] | ||
**Adult: 0.4-2mg IV | |||
Adult: 0.4-2mg IV | **Peds: 0.1mg/kg IV (max 2mg) | ||
Peds: 0.1mg/kg IV (max 2mg) | |||
|- | |- | ||
| [[Cyanide]] | | [[Cyanide]] | ||
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Fomepizole | Fomepizole | ||
*15mg/kg IV; then 10mg/kg q12h | |||
15mg/kg IV; then 10mg/kg q12h | |||
|- | |- | ||
| Fluoride | | Fluoride | ||
Revision as of 05:52, 9 June 2016
| TOXIN | ANTIDOTE |
| Acetaminophen |
|
| Anticholinergics | Physostigmine |
| Arsenic | Dimercaprol (BAL) |
| Benzodiazepines |
|
| Beta blockers |
|
| Ca channel blockers |
Calcium chloride 10%
High Dose Insulin (1 unit/kg/hr) |
| Clonidine |
|
| Cyanide |
Hydroxycobalamin OR Cyanide Antidote Kit (Amyl Nitrite, Sodium Nitrite, and Sodium Thiosulfate) |
| Digoxin | Dig Immune Fab |
| Ethylene glycol |
Fomepizole
|
| Fluoride | Calcium Gluconate |
| Heparin |
Protamine Sulfate Adult: 25-50mg IV (empiric dose) over 10 minutes Peds: 0.6mg/kg IV (empiric dose) Note: Rapid protamine infusion causes hypotension[1] |
| Iron | Deferoxamine |
| Isoniazid (INH) |
Pyridoxine (Vit B6) Adult: 5gm IV Peds: 1gm/kg regardless of age [2] |
| Lead | EDTA, succimer |
| Mercury | Dimercaprol (BAL) |
| Methanol | Fomepizole
15mi/kg IV; then 10mg/kg q12h |
| Methemoglobinemia | Methylene blue |
| Opiods | Naloxone |
| Organophosphates | Atropine + Pralidoxime |
| Sulfonylurea |
Octreotide Adult: 50–100mcg SC q6hr Peds: 1mcg/kg SC q6hr |
| Tricyclic (TCA) Toxicity |
Bicarbonate 1-2mEq/kg IV bolus followed by 2mEq/kg/hr IV infusion |
| Valproate | L-Carnitine |
| Warfarin | Vitamin K, FFP, Prothrombin Complex Concentrates |
Source
<references>