Thiamine: Difference between revisions
Ostermayer (talk | contribs) (Text replacement - "Category:Drugs" to "Category:Pharmacology") |
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***Then 5-30 mg PO qd x1mo | ***Then 5-30 mg PO qd x1mo | ||
*Wet beriberi | *Wet beriberi with CHF | ||
**10-30 mg IV tid | **10-30 mg IV tid | ||
Revision as of 05:59, 13 July 2016
Administration
- Dosage Forms: 50,100,250,500mg
- Routes of Administration: IM, IV
- Im or IV routres require: Intradermal skin test before use if hypersensitivity risk
- Common Trade Names: Vitamin B1
Adult Dosing
- Beriberi
- 10-20 mg IM tid x 2wk
- Then 5-30 mg PO qd x1mo
- 10-20 mg IM tid x 2wk
- Wet beriberi with CHF
- 10-30 mg IV tid
- Wernicke encephalopathy
- 100 mg IV x1
- Then 50-100 mg IM/IV qd
- 100 mg IV x1
Pediatric Dosing
Special Populations
- Pregnancy Rating: A (according to dietary reference intake)
- Lactation risk: Safe
Renal Dosing
Not defined
Hepatic Dosing
Not defined
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- anaphylaxis
- angioedema
- cyanosis
Common
- injection site pain
- pruritus
- warmth sensation
- urticaria
Pharmacology
- Half-life: Unknown
- Metabolism: Liver, CYP450, Unknown
- Excretion: Urine
Mechanism of Action
Physiologic cofactor