Neuromuscular blocking agents
Revision as of 03:30, 24 February 2015 by Rossdonaldson1 (talk | contribs)
Background
- Non-depolarizing
- Competitively block binding of ACh to its receptors
- Depolarizing
- Depolarizing skeletal muscle fiber
- Persistent depolarization makes the muscle fiber resistant to further stimulation by ACh
Types
| Agent | Time to onset (seconds) |
Duration (minutes) |
Side effects | Clinical use |
|---|---|---|---|---|
| Non-Depolarizing | ||||
| Succinylcholine | fasciculations, post-operative pain | |||
| Depolarizing | ||||
| Atracurium (Tracrium) | 90 | 30 min or less[1] |
|
widely[1] |
| Cisatracurium (Nimbex) | 90 | 60–80 | does not cause release of histamine | |
| Vecuronium (Norcuron) | 60 | 30–40[1] | Few,[1] may cause prolonged paralysis[1] and promote muscarinic block | widely[1] |
| Rocuronium (Zemuron) | 75 | 45–70[citation needed] | may promote muscarinic block | |
| Pancuronium (Pavulon) | 90 | 180 or more[citation needed] |
(no hypotension)[1] |
widely[1] |