Unknown Source

	Harbor-UCLA	Santa Monica-UCLA
Community Acquired	[[Ceftriaxone]] 1 g IV + Vancomycin 1 g IV + Gentamicin 5mg/kg + Metronidazole 500mg g IV	Piperacillin/tazobactam 4.5g IV q6h OR cefepime 1g IV q8h OR meropenem 1g IV q8h +/- vancomycin 15mg/kg/dose IV q12h (Max dose = 1500mg) +/- gentamicin 7mg/kg/dose IV q24h +/- fluconazole 400mg IV q24h
Health Care Associated (or allergy)	Option 1: Cefepime 2 g IV + Vancomycin 1 g IV + Gentamicin 5-7mg/kg + Metronidazole 500mg g IV Option 2: Meropenem 2 g IV + Vancomycin 1 g IV	aztreonam 2g IV q8h OR levofloxacin 750mg IV q24h +/- vancomycin 15mg/kg/dose IV q12h (Max dose = 1500mg) +/- gentamicin 7mg/kg/dose IV q24h +/- fluconazole 400mg IV q24h

Intra-Abdominal

	Harbor-UCLA	Santa Monica-UCLA	Other
Primary	Metronidazole 500mg IV q8hrs Plus one of the following: Ceftriaxone 1g IV once daily Ciprofloxacin 400mg IV q12hrs Cefazolin 1g (30mg/kg) IV q8hrs Levofloxacin 750mg IV once daily	Metronidazole 500mg IV q8h + Vancomycin 15mg/kg/dose IV q12h (Max dose = 1500mg) Plus one of the following: Piperacillin/tazobactam 4.5g IV q6h Ertapenem 1g IV q24h Ceftriaxone 1g IV q24h	One of the following: Piperacillin-tazobactam Ticarcillin-clavulanate 3.1 g IV every 6 hours Ertapenem 1 g every 24 hours Moxifloxacin 400 mg IV every 24 hours
Allergy or prior exposure	Piperacillin/Tazobactam 4.5g (80mg/kg) IV q8hrs OR Metronidazole 500mg IV q8hrs PLUS Cefepime 2g IV once daily OR Ciprofloxacin 400mg IV q12hrs OR Levofloxacin 750mg IV once daily Meropenem 1g (20mg/kg) IV q8hrs OR Doripenem 500mg IV q8hrs OR Aztreonam 2g (30mg/kg) IV q8hrs + Metronidazole 500mg IV q8hrs	aztreonam 2g IV q8h + metronidazole 500mg IV q8h +/- vancomycin 15mg/kg/dose IV q12h (Max dose = 1500mg)

Metronidazole 7.5mg/kg IV q8hrs (max 500mg) + one of:
- Ceftriaxone 50-75mg/kg IV daily (max 2g) OR
- Cefotaxime 50mg/kg IV q8hrs (max 2g/dose)
Piperacillin/Tazobactam 80-100mg/kg IV q6-8hrs (max 4.5g) OR
Meropenem 20mg/kg IV q8hrs (max 1g)

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