Alpha blockers
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Background
- Also known as α-blockers
- α1-blockers act on α1-adrenoceptors
- α2-blockers act on α2-adrenoceptors
- Act as neutral antagonists or inverse agonists of α-adrenergic receptors (α-adrenoceptors)
Medications
Non-selective
- Phenoxybenzamine
- Phentolamine
- Tolazoline
- Trazodone
- Typical and atypical antipsychotics
Selective Alpha 1
Selective Alpha 2
Mixed
- The agents carvedilol and labetalol are both α- and β-blockers.
Uses
- hypertension
- Raynaud's disease
- scleroderma
- generalized anxiety disorder
- panic disorder
- posttraumatic stress disorder (PTSD).
- benign prostatic hyperplasia