Fludrocortisone
Administration
- Type: Corticosteroid
- Dosage Forms:
- Routes of Administration: PO
- Common Trade Names:
Adult Dosing
- 0.1 mg 3 times per week to 0.2 mg daily
Pediatric Dosing
NOT FDA approved in children
- 0.05-0.2 mg/day
Special Populations
- Pregnancy Rating: C
- Lactation risk: Infant risk cannot be ruled out
- Renal dosing: no adjustment
- Hepatic dosing: no adjustment
Contraindications
- Allergy to class/drug
- Systemic fungal infections
Adverse Reactions
Serious
- Secondary adrenal insufficiency
- Elevated ICP, seizure
- CHF, cardiomegaly, hypertension
- Thrombophlebitis
Common
- Bruising, petechiae
- Impaired wound healing
- Hyperglycemia, hypokalemia
- Rash, urticaria
- Peptic ulcer disease
- Irregular menses, growth delay (children)
- Headache, vertigo
Pharmacology
- Half-life: 3.5 hours
- Metabolism: Hepatic
- Excretion:
Mechanism of Action
- Very potent mineralocorticoid, also has glucocorticoid effects