Hemochromatosis
Revision as of 21:49, 18 March 2017 by Unenthusiastic (talk | contribs) (Created page with "==Background== *accumulation of iron in the body *most commonly due to hereditary hemochromatosis (HHC) and transfusional iron overload **Hereditary hemochromatosis most commo...")
Background
- accumulation of iron in the body
- most commonly due to hereditary hemochromatosis (HHC) and transfusional iron overload
- Hereditary hemochromatosis most common in people of Celtic ancestry
- AKA "bronze diabetes"
Clinical Features
- Cirrhosis
- Diabetes due to iron deposition in pancreatic beta cells
- Cardiomyopathy
- Arthritis: knuckles of the second and third fingers most common
- Bronzing of the skin
Differential Diagnosis
Evaluation
- Serum ferritin:
- >300 ng/mL in males and postmenopausal women
- >150 - 200 ng/mL in premenopausal women
Management
- Phlebotomy
- Chelation with deferoxamine