Sodium thiosulfate
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Administration
- Type:
- Dosage Forms:
- Routes of Administration:
- Common Trade Names:
Adult Dosing
Cyanide toxicity
- Adult: 12.5 g IV
Prophylaxis during nitroprusside infusion
- Add 10 mg sodium thiosulfate for each 1 mg of nitroprusside
Pediatric Dosing
Cyanide toxicity
- Pediatric: 400 mg/kg IV
Prophylaxis during nitroprusside infusion
- Add 10 mg sodium thiosulfate for each 1 mg of nitroprusside
Special Populations
- Pregnancy Rating: C
- Lactation risk:
Renal Dosing
- Adult:
- Pediatric:
Hepatic Dosing
- Adult:
- Pediatric:
Indications
- Acute cyanide toxicity
- Smoke inhalation with potential for cyanide exposure
- Prophylaxis during nitroprusside infusions
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
Common
- Burning sensation and muscle cramping from infusion
Pharmacology
- Half-life:
- Metabolism:
- Excretion:
Mechanism of Action
Comments
- Sulfur donor that promotes conversion of cyanide to thiocyanate
- Whereas the nitrites have adverse effects, sodium thiosulfate is non-toxic
See Also
References
- Olson, K. Poisoning and Drug Overdose, 1999.