D-dimer

• Factors that can cause false-negative D-dimer
  • Symptoms of PE > 3 days
  • Small PE
  • Use of qualitative latex fixation test
  • Use of anticoagulants
• Factors that can cause false-positive D-dimer
  • Cancer and malignancy
  • Recent surgery
  • Infection (eg, PNA, sepsis)
  • Pregnancy
  • Age > 70 years
  • DIC
  • Trauma
  • Arterial thrombosis
  • ACS/AMI
  • Vaso-occlusive sickle cell crisis
  • Acute CVA
  • Vasculitis
  • Superficial phlebitis

See Also

Pulmonary Embolism (PE)

Source

D-dimer threshold increase. Kline et. al.

• EBmedicine.net