EBQ:MATTERs Study
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Under Review Journal Club Article
Morrison J. et al. "Military Application of Tranexamic Acid in Trauma Emergency Resuscitation (MATTERs) Study". JAMA Surgery. 2012. 147(2):113-119.
PubMed Full text PDF
PubMed Full text PDF
Clinical Question
Does administration of Tranexamic (TXA) acid in trauma patients with hemorrhage improve mortality in a wartime setting?
Conclusion
The use of TXA with blood component-based resuscitation following combat injury results in improved measures of coagulopathy and survival, a benefit that is most prominent in patients requiring massive transfusion