Antidotes
|
TOXIN |
ANTIDOTE |
| Acetaminophen |
N-acetylcysteine 150mg/kg IV load over 60min; followed by 50mg/kg IV over 4hr and then 100mg/kg IV over 16hr |
| Antidepressants (TCA) |
Bicarbonate 1-2mEq/kg IV bolus followed by 2mEq/kg/hr IV infusion |
| Arsenic | Dimercaprol (BAL) |
| Benzodiazepines |
Flumazenil Adult: 0.2mg IV Peds: 0.01mg/kg IV |
| Beta blockers |
Glucagon Adult: 3-10mg IV Peds: 50-150mcg/kg IV |
|
Calcium chloride 10% Adult: 10 mL IV Peds: 0.2-0.25 mL/kg IV | |
|
Clonidine |
Naloxone Adult: 0.4-2mg IV Peds: 0.1mg/kg IV (max 2mg) |
| Cyanide |
Kit- Hydroxycobalamin, Sodium nitrite, Sodium thiosulfate |
| Digoxin | Dig Immune Fab |
| Ethylene glycol |
Fomepizole 15mi/kg IV; then 10mg/kg q12h |
| Fluoride | Calcium Gluconate |
| Heparin |
Protamine Adult: 25-50mg IV (empiric dose) over 10 minutes Peds: 0.6mg/kg IV (empiric dose) rapid protamine infusion causes hypotension[1] |
| Iron | Deferoxamine |
| Isoniazid (INH) |
Pyridoxine (Vit B6) Adult: 5gm IV Peds: 1gm/kg regardless of age [2] |
| Lead | EDTA, succimer |
| Mercury | Dimercaprol (BAL) |
| Methanol | Fomepizole
15mi/kg IV; then 10mg/kg q12h |
| Methemoglobin | Methylene blue |
| Opiods | Nalaxone |
| Organophosphates | Atropine+pralidoxime |
| Sulfonylurea |
Octreotide Adult: 50–100mcg SC q6hr Peds: 1mcg/kg SC q6hr |
| Valproate | Carnitine |
| Warfarin | Vit K, FFP, Prothrombin Complex Concentrates |
Source
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