Factor V Leiden
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Background
- Also known as Factor V Leiden Deficiency or FVL
- Point mutation in FV making it resistant to cleavage by activated protein C
- Increased risk of thrombosis
- Most individuals with FVL will never have a venous thromboembolism (VTE)
Clinical Features
- family history of thrombophilia
- VTE at a young age
- VTE in an atypical location