Propranolol

General

• Type: Beta blockers, nonselective
• Dosage Forms:
  • IV: 1mg/mL
  • PO conventional: 10, 20, 40, 60, 80 mg
  • PO extended release: 60, 80, 120, 160 mg
• Common Trade Names: Inderal

Adult Dosing

• Thyroid storm
  • 1-2mg IV over 10 min; if tolerates then 1-2mg boluses q15 minutes until HR <100
  • May follow with gtt @ dose required for HR control (ie 3-5 mg/hr)
  • Alternate 60-80 mg PO q4h
• Variceal bleed ppx
  • 20 mg bid titrated up to max tolerated dose
• Migraine ppx
  • Starting dose 80 mg daily as either XL or divided q6-8hr. Max 160-240 mg/day
• Essential tremor
  • 40 mg bid starting dose
• HOCM
  • 80-160 mg daily as either XL or divided q6-8 hr

Special Populations

• Pregnancy Rating:
• Lactation:
• Renal Dosing
  • Adult
  • Pediatric
• Hepatic Dosing
  • Adult
  • Pediatric

Contraindications

• Allergy to class/drug

Pharmacology

• Half-life:
• Metabolism:
• Excretion:
• Mechanism of Action: