Leucovorin

Administration

• Type: Antidote; Chemotherapy Modulating Agent; Rescue Agent (Chemotherapy)
• Dosage Forms: 5,10,15,25
• Routes of Administration: IV, IM
• Common Trade Names: Lederle Leucovorin

Adult Dosing

Indications by Disease

Disease	Dose	Context
Toxoplasmosis	10mg PO q24hrs	Immunocompetent adjunct
Toxoplasmosis	25mg PO q24hrs	Immunosuppressed adjunct

Pediatric Dosing

Indications by Disease

Disease	Dose	Context
Toxoplasmosis	10mg PO 3x/week	Congenital/Pediatric adjunct

Special Populations

• Pregnancy Risk Factor: C
• Breast Feeding: Leucovorin is a form of folic acid and is present in breast milk which may be beneficial to the newborn.

Renal Dosing

• Not defined

Hepatic Dosing

• Not defined

Contraindications

• Allergy to class/drug
• intrathecal administration
• caution if pernicious anemia
• caution if megaloblastic anemia, vitamin B12 deficient
• caution if vitamin B-12 deficiency

Adverse Reactions

Serious

• anaphylactoid reaction
• seizures
• syncope

Common

• urticaria
• nausea/vomiting (IV use)

Pharmacology

• Half-life: 6hr
• Metabolism: liver, GI, CYP450
• Excretion: Urine

References

<Epocrates, UpToDate>