Miconazole
Administration
- Type: Antifungal
- Dosage Forms: 2% Cream
- Routes of Administration: Topical
- Common Trade Names: Monistat-Derm, Desenex, Lotrimin, Micatin, Zeasorb
Adult Dosing
Indications by Disease
| Disease | Dose | Context |
|---|---|---|
| Candida vulvovaginitis | 2% cream applied vaginally for 7 days OR 4% cream x 3 days | Intravaginal therapy |
| Candidiasis | 2% cream applied topically BID x 2 weeks | Cutaneous candidiasis |
| Tinea corporis | 2% cream applied topically BID x 4 weeks | Mild disease |
| Tinea cruris | 2% cream applied topically BID x 2 weeks | Topical antifungal |
| Tinea pedis | 2% cream applied topically BID x 4 weeks | Topical antifungal |
Pediatric Dosing
Indications by Disease
Special Populations
Pregnancy Rating
- Risk of fetal harm no expected
- May use during pregnancy
Lactation risk
- May use while breastfeeding
Renal Dosing
- Adult: Not defined
- Pediatric: Not defined
Hepatic Dosing
- Adult: Not defined
- Pediatric: Not defined
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- May occur, but none reported
Common
- Irritation, burning, stining
- Pruritus, erythema, maceration
- Contact dermatitis
Pharmacology
- Half-life: Unknown
- Metabolism: None, minimal systemic absorption
- Excretion: None
Mechanism of Action
- Inhibits 14-alpha demethylase, reducing fungal cell membrane ergosterol synthesis