Miconazole
Administration
- Type: Antifungal
- Dosage Forms: 2% Cream
- Routes of Administration: Topical
- Common Trade Names: Monistat-Derm, Desenex, Lotrimin, Micatin, Zeasorb
Adult Dosing
Candidiasis, cutaneous
- Apply 2% Cream BID to affected area x2 weeks
Tinea corporis
- Apply 2% Cream BID to affected area x4 weeks
Tinea cruris
- Apply 2% Cream BID to affected area x2 weeks
Tinea pedis
- Apply 2% Cream BID to affected area x4 weeks
Indications by Disease
| Disease | Dose | Context |
|---|---|---|
| Candida vulvovaginitis | 2% cream applied vaginally for 7 days OR 4% cream x 3 days | Intravaginal therapy |
| Candidiasis | 2% cream applied topically BID x 2 weeks | Cutaneous candidiasis |
| Tinea corporis | 2% cream applied topically BID x 4 weeks | Mild disease |
| Tinea cruris | 2% cream applied topically BID x 2 weeks | Topical antifungal |
| Tinea pedis | 2% cream applied topically BID x 4 weeks | Topical antifungal |
Pediatric Dosing
Candidiasis, cutaneous
- Apply 2% Cream BID to affected area x2 weeks
Tinea corporis
- Apply 2% Cream BID to affected area x4 weeks
Tinea cruris
- Apply 2% Cream BID to affected area x2 weeks
Tinea pedis
- Apply 2% Cream BID to affected area x4 weeks
Indications by Disease
Special Populations
Pregnancy Rating
- Risk of fetal harm not expected
- May use during pregnancy
Lactation risk
- May use while breastfeeding
Renal Dosing
- Adult: No adjustment needed
- Pediatric: No adjustment needed
Hepatic Dosing
- Adult: No adjustment needed
- Pediatric: No adjustment needed
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- Anaphylaxis (rare)
Common
- Skin irritation
- Burning
- Pruritus
Pharmacology
- Metabolism: Hepatic
- Info: Minimal systemic absorption from topical use
Mechanism of Action
- Azole antifungal
- Inhibits ergosterol synthesis in fungal cell membranes