Disulfiram effect
Background
- Disulfiram (Trade names: Antabuse, Antabus) - causes an acute reaction in the presence of ethanol.
- Works by inhibiting acetaldehyde dehydrogenase → buildup of acetaldehyde → unpleasant effects.
- Designed to assist in alcohol cessation.
Clinical Features
Differential Diagnosis
Diagnosis
- Clinical diagnosis
Medications with Similar Effects
- Antibiotics (metronidazole, cephalosporins (cefotetan))
- Antifungals (Griseofulvin)
Management
- Supportive care