Harbor:Sepsis antibiotics

Unknown Source

    A. Comm. Acquired          Vanco 1 g IV

         Ceftriaxone 1 g IV

         Metronidazole 1.5 g IV

         Gentamicin 5mg/kg

    B. Healthcare Assoc.          Vanco 1 gm IV

         Cefepime 2g gm IV

         Metronidazole 1.5 g IV

         Gentamicin 5-7 mg/kg

    C. Cephalosporin allergy          Vanco 1 gm IV

         Metronidazole 1.5 g IV

         Gentamicin 5-7 mg/kg IV

         Levofloxacin 750mg IV

Pneumonia (Community)

    A. Comm. Acquired          Ceftriaxone 1 gm IV

         Azithromycin 500 mg IV

         OR

         Doxycycline 100mg IV

    C. Cephalosporin allergy          Moxifloxacin 400 mg IV

         OR

         Levofloxacin 750mg IV

Pneumonia (Healthcare Assoc/Pseudomonas Risk)

    B. Healthcare Assoc.          Cefipime 2 g IV

         Cipro 400 mg IV

         Clinda 600 mg IV

    C. Cephalosporin allergy          Clinda 600 mg IV

         Cipro 400 mg IV

         Gentamicin 5-7 mg/kg IV

Abdominal/Pelvic

    A. Comm. Acquired          Ceftriaxone 1 g IV

         Metronidazole 1.5 g IV

         Gentamicin 5-7 mg/kg IV

    B. Healthcare Assoc.          Ceftazidime 2 g IV

         Gentamicin 5 mg/kg IV

         Metronidazole 1.5 mg IV

    C. Cephalosporin allergy          Cipro 400 mg IV

         Metronidazole 1.5 g IV

         Gentamicin 5-7 mg/kg IV

Urosepsis

    A. Comm. Acquired          Ceftriaxone 1 g IV

         Gentamicin 5-7 mg/kg IV

    B. Healthcare Assoc.          Vancomycin 1 g IV

         Ceftazidime 1g IV

         Gentamicin 5-7 mg/kg IV

    C. Cephalosporin allergy          Vancomycin 1g IV

         Cipro 400 mg IV

         Gentamicin 5 mg/kg IV

Meningitis (Nl/Community)

    A. Comm. Acquired          Ceftriaxone 2 g IV

         Vancomycin 1.5 g IV

    C. Cephalosporin allergy          Chloramphenicol 1 g IV

         Vancomycin 1.5g IV

Meningitis (Nl/Post neurosurgical)

    B. Healthcare Assoc.          Vanco 1.5 g IV

         Cefepime 2 g IV

    C. Cephalosporin allergy          Vanco 1.5g IV

         Cipro 400mg IV

Meningitis (Immunocomp)

(Cirrhosis, EtoH, age > 65, steroids, HIV)

    A. Comm. Acquired          Penicillin G 4M Units IV

         Ceftriaxone 2 g IV

         Vancomycin 1g IV

    C. Cephalosporin allergy          Chloramphenicol 1g IV

         Trim/sulfa 10mg/kg IV

         Vancomycin 1.5g IV

Necrotizing Soft-tissue Infection

    A. Comm. Acquired/Healthcare Assoc.          Vanco 1 gm IV

         Ceftriaxone 1 gm IV

         Clinda 600 mg IV

         Consider: Gent 5-7mg/k IV

    B. Healthcare Assoc.          Vancomycin 1g IV

         Piperacillin/Tazobactam 3.375g IV

         Clindamycin 600mg IV

    C. Cephalosporin allergy          Vanco 1 gm IV

         Clinda 600 mg IV

         Cipro 400 mg IV

         Gentamicin 5-7mg/kg

Adapted by DONALDSON from Harbor-UCLA Abx-Review Committee (Rev. 07/27/06)