Oseltamivir

Administration

• Type: Antiviral
• Routes of Administration: Oral
• Common Trade Names: Tamiflu

Adult Dosing

Influenza

• 75mg PO BID x 5 days

Pediatric Dosing

Influenza

• Age <1 year: 3mg/kg PO BID x 5 days
• <15kg: 30mg PO BID x 5 days
• 15-23kg: 45mg PO BID x 5 days
• 24-40kg: 60mg PO BID x5d
• Adult: 75mg PO BID x 5 days

Special Populations

• Pregnancy Rating:
• Lactation risk:
• High Risk for Complications and Recommended for Treatment per CDC:
  • Children < 2 yo
  • Adults > 65 yo
  • Chronic Pulmonary Disease including Asthma
  • Cardiovascular disease (excluding HTN only)
  • Renal, hepatic, hematological, and metabolic disorders (including sickle cell, diabetes)
  • Neurological and Neurodevelopmental disorders (brain disorders, spinal cord, peripheral nerve disorders, cerebreal palsy, epilepsy, stroke, MR, developmental delay, muscular dystrophy)
  • Immunosuppressed including on HAART
  • Pregnant or Postpartum (2 weeks after delivery)
  • <19 yo on long term aspirin
  • American Indians/Alaskan natives
  • Morbid Obesity (BMI >= 40)
  • Nursing home or chronic care facility residents.

Renal Dosing

• Adult:
• Pediatric:

Hepatic Dosing

• Adult:
• Pediatric:

Contraindications

• Allergy to class/drug

Pharmacology

• Half-life:
• Metabolism:
• Excretion:

Comments

• Influenza
  • Shortens duration of illness by 16.8 hrs while NNTH (number needed to harm) was 28 in regards to causing n/v, HA, and renal and psych syndromes
  • Greatest benefit if within 48hrs of symptom onset
    • However, may be beneficial up to 4-5 days, including in pregnant patients
    • Early treatment of hospitalized pts can reduce death