Serum sickness

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Background

  • A type III hypersensitivity reaction
    • Secondary to injection of anitoxins (e.g. tetanus, rabies)
  • Reactions secondary to the administration of nonprotein drugs
    • Amoxicillin, cefaclor, cephalexin (Keflex), trimethoprim-sulfamethoxazole

Treatment

  1. D/C antigen


Prognosis

  1. Symptoms usually last 1-2 weeks before spontaneously subsiding
  2. Long-lasting sequelae generally do not occur
  3. Fatalities are rare and usually are due to continued administration of the antigen