Tamsulosin

Administration

• Type: Alpha blocker
• Dosage Forms:
• Routes of Administration: oral
• Common Trade Names: Flomax

Adult Dosing

• 0.4mg PO once daily

Pediatric Dosing

Safety/efficacy not established

Special Populations

• Pregnancy Rating: B
• Lactation risk: Infant risk cannot be ruled out

Renal Dosing

• Adult: No adjustment for CrCl >10

Hepatic Dosing

• Adult: No adjustment

Contraindications

• Allergy to class/drug

Adverse Reactions

Serious

• Retinal detachment
• Priapism

Common

• Headache, dizziness, insomnia, somnolence
• Abnormal ejaculation
• Rhinitis
• Back pain

Pharmacology

• Half-life: 9-15h
• Metabolism: CYP3A4 and CYP2D6
• Excretion: Mostly renal

Mechanism of Action

• Alpha-1A antagonist--> smooth muscle relaxation in bladder neck, prostate, urethra--> increased urine flow rate

See Also

• EBQ:Alpha-blockers for ureteral stone expulsion